Organic Chemistry II 310-ERS-CHOR2E
Wykład (WYK) Rok akademicki 2024/25

Literature:

McMurry J., Fundamentals of Organic Chemistry, Pacific Grove, CA: Brooks/Cole Pub. Co., 1998.

Morrison R.T., Boyd R.N., Organic Chemistry, 7th edition, Pearson, 2008.

Hallas G. Organic Stereochemistry, McGraw-Hill. London, New York 1965.

Complementary literature:

Smith, M. B., March J., March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, Wiley-Interscience, 2001.

Knowledge:

The student knows and understands the issues of organic chemistry,

allowing him to discuss the structure of organic compounds (taking

into account their spatial structure), their physical and chemical

properties, explain the mechanisms of reactions, use chemical

terminology and nomenclature.

Knows and understands methods of synthesis, purification and

identification of organic compounds.

The student knows and understands the issues of occupational safety

and health, in particular, knows the principles of safe handling of

chemicals and the selection and disposal of chemical waste

(KP6_WG1-WG5, KP6_WG7, KP6_WG13).

Abilities:

The student is able to identify and solve chemical problems based on

the acquired knowledge, including complex and unusual problems, plan

and perform experimental investigations.

The student is able to plan and carry out the synthesis of organic

compounds, has mastered the manual skills necessary for the work, and

can operate the necessary laboratory equipment and scientific

apparatus.

The student is able to observe experiments and draw conclusions from

them, and develop the results in written form (report/report).

Can purify and identify organic compounds using classical and

spectroscopic methods.

Maintains health and safety rules recommended in a laboratory environment.

Able to work in a group, as well as independently. (KP6_UW1-KP6_UW4,

KP6_UW6, KP6_UU1, KP6_UO1)

Competencies:

The student is ready to take an interest in chemical processes

occurring in the environment. (KP6_KO1)

Methods and evaluation criteria:

- written exam

- reports and written tests of laboratory exercises

- written tests from the conversion course

- Systematic evaluation of work in the conversation room and laboratory exercises.

Grading criteria in accordance with the Academic Regulations.

1. Aldehydes and Ketones- Nucleophilic Addition Reactions; Nucleophilic Addition of Water- Hydration; Nucleophilic Addition of HCN - Cyanohydrin Formation; Nucleophilic Addition of Hydride and Grignard Reagents - Alcohol Formation; Nucleophilic Addition of Amines - Imine and Enamine Formation; Nucleophilic Addition of Hydrazine - The Wolff-Kishner Reaction; Nucleophilic Addition of Alcohols - Acetal Formation; Conjugate Nucleophilic Addition to alpha, beta-unsaturated Aldehydes and Ketones; Preparing Aldehydes and Ketones, Oxidation of Aldehydes and Ketones.

2. Carboxylic Acids and Nitriles; Structure and Properties of Carboxylic Acids; Substituent Effects on Acidity; Preparing Carboxylic Acids.

3. Carboxylic Acid Derivatives- Nucleophilic Acyl Substitution Reactions; Chemistry of Acyl Halides, Acid Anhydrides and Esters.

4. Carbonyl Alpha-Substitution Reactions; Keto-Enol Tautomerism; Alpha Halogenation of Aldehydes and Ketones - Haloform Reaction.

5. Carbonyl Condensation Reactions - The Aldol Reaction; Dehydration of Aldol Products - Synthesis of Enones; Mixed Aldol Reactions; The Claisen Condensation Reaction; Intramolecular Claisen Condensations - The Dieckmann Cyclization; Conjugate Carbonyl Additions - The Michael Reaction; The Robinson Annulation Reaction.

6. Aliphatic and Aromatic Amines; Structure and Basicity of Amines; Reactions of Amines and Arylamines.

7. Amides; Preparing Amides; Beckmann rearrangement, Hofmann degradation of amides; Curtius Rearrangement; Gabriel Synthesis; Peptides.

8. Heteroaromatic Compounds; The Structure of Furan, Pyrrole, thiophene, and Pyridine; Synthesis of Heterocyclic Rings; Electrophilic substitution reactions of heteroaromatic compounds; Nucleophilic Substitution of Pyridine - Chichibarin Reaction.

9. Biomolecules - carbohydrates, proteins, lipids.

lecture, problem/conversation lecture