Organic Chemistry II 310-ERS-CHOR2E
Wykład (WYK) Rok akademicki 2023/24

Literature:

McMurry J., Fundamentals of Organic Chemistry, Pacific Grove, CA: Brooks/Cole Pub. Co., 1998.

Morrison R.T., Boyd R.N., Organic Chemistry, 7th edition, Pearson, 2008.

Hallas G. Organic Stereochemistry, McGraw-Hill. London, New York 1965.

Complementary literature:

Smith, M. B., March J., March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, Wiley-Interscience, 2001.

1. Aldehydes and Ketones - nucleophilic addition reactions (addition of water, HCN, alcohol, nitrogen nucleophiles, complex metal hydride, and Grignard reagents. Nucleophilic addition to alpha,beta-unsaturated aldehydes and ketones; aldehyde and ketone synthesis methods; oxidation of Aldehydes and Ketones.

2. Carboxylic Acids and Nitriles; - structure and properties of Carboxylic Acids; substituent effects on acidity; carboxylic acid and nitrile synthesis method.

3. Carboxylic acid derivatives - nucleophilic acyl substitution reactions; chemistry of acyl halides, acid anhydrides, esters.

4. Carbonyl alpha-substitution reactions; keto-enol tautomerism; alpha halogenation of aldehydes and ketones - haloform reaction, alkylation.

5. Carbonyl condensation reactions - aldol reaction; dehydration of adol products - synthesis of enones; mixed adol reactions; Claisen condensation Dieckmann cyclization; conjugate carbonyl additions - Michael reaction;

6. Aliphatic and aromatic amines - structure and basicity of amines; reactions and synthesis methods of amines and arylamines.

7. Amides - Aamide synthesis; Beckmann rearrangement, Hofmann degradation; Curtius rearrangement; Gabriel synthesis

8. Heteroaromatic compounds; - the structure of furan, pyrrole, thiophene, and pyridine; synthesis of heterocyclic rings; electrophilic substitution reactions of heteroaromatic compounds; nucleophilic substitution of pyridine - Chichibabin reaction.

9. Biomolecules - carbohydrates, proteins, lipids.